Journal article
Meta-analysis supports GWAS-implicated link between GRM3 and schizophrenia risk
SM Saini, SG Mancuso, MS Mostaid, C Liu, C Pantelis, IP Everall, CA Bousman
Translational Psychiatry | SPRINGERNATURE | Published : 2017
DOI: 10.1038/TP.2017.172
Abstract
Genome-wide association study (GWAS) evidence has identified the metabotropic glutamate receptor 3 (GRM3) gene as a potential harbor for schizophrenia risk variants. However, previous meta-analyses have refuted the association between GRM3 single-nucleotide polymorphisms (SNPs) and schizophrenia risk. To reconcile these conflicting findings, we conducted the largest and most comprehensive meta-analysis of 14 SNPs in GRM3 from a total of 11 318 schizophrenia cases, 13 820 controls and 486 parent–proband trios. We found significant associations for three SNPs (rs2237562: odds ratio (OR) = 1.06, 95% confidence interval (CI) = 1.02–1.11, P = 0.017; rs13242038: OR = 0.90, 95% CI = 0.85–0.96, P = ..
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Awarded by Brain and Behavior Research Foundation
Funding Acknowledgements
SMS was supported by a Ministry of Higher Education Malaysia Scholarship and the National University of Malaysia. MSM was supported by a Cooperative Research Centre for Mental Health Top-up Scholarship. CP was supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (ID: 1105825), and a Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award. CAB was supported by an NHMRC Career Development Fellowship (ID: 1127700).